Peptic Ulcer
Peptic ulcer disease is a common disorder that affects millions of individuals each year, with a major impact on health care cost. Peptic ulcer is an erosion in the mucosa and can occur in any area that is exposed to gastric acid and pepsin, including the lower esophagus, stomach and duodenum. This erosion leaves the underlying layers of cells unprotected and exposed to gastric juices. If a peptic ulcer is located in the stomach it is called a gastric ulcer.
Normal gastric and duodenal mucosa is protected from the digestive actions of acid and pepsin by the secretion of mucus, the production of bicarbonate, the removal of excess acid by normal blood flow, and the rapid renewal and repair of epithelial cell injury. When protective factors are impaired or dimished, acid and pepsin can damage the mucosal lining.